ABO blood group is a determinant of von Willebrand factor protein levels in human pulmonary endothelial cells
نویسندگان
چکیده
منابع مشابه
ABO blood group antigens on human plasma von Willebrand factor after ABO-mismatched bone marrow transplantation.
von Willebrand factor (vWF) is synthesized exclusively by endothelial cells and megakaryocytes, and stored in the intracellular granules or constitutively secreted into plasma. ABO blood group antigens are covalently associated with asparagine-linked sugar chains of plasma vWF. The effect of ABO-mismatched bone marrow transplantation (BMT) or blood stem cell transplantation (BSCT) on the expres...
متن کاملABO blood group and von Willebrand factor levels partially explained the incomplete penetrance of congenital thrombophilia.
OBJECTIVE We aimed to study the association among ABO blood group, von Willebrand factor, factor VIII plasma levels, and the risk of venous thrombosis (VT) in a cohort of 1774 relatives from 500 families with inherited thrombophilia. METHODS AND RESULTS One hundred sixty-one of the 1774 relatives had a VT. Different risk groups were formed: no, low-(factor V Leiden or F2G20210A heterozygous c...
متن کاملRelationship between ABO blood group and von Willebrand factor levels: from biology to clinical implications
Although a number of studies have demonstrated the influence of ABO blood group on plasma levels of von Willebrand factor (VWF), the nature of this association and its clinical importance is still largely unknown.In this review, the most recent advances in our understanding of the mechanisms by which ABO blood group determines plasma VWF levels and their clinical impact will be discussed.
متن کاملFactor VIII/von Willebrand factor protein. Galactose a cryptic determinant of von Willebrand factor activity.
The normal Factor VIII/von Willebrand factor protein has the ability to agglutinate or aggregate normal platelets in the presence of ristocetin (von Willebrand factor activity). Removal of greater than 95% of the sialic acid from this protein by neuraminidase did not affect the von Willebrand factor or procoagulant activity. However, oxidation of the penultimate galactose of the asialo Factor V...
متن کاملAmount of H antigen expressed on circulating von Willebrand factor is modified by ABO blood group genotype and is a major determinant of plasma von Willebrand factor antigen levels.
To investigate whether the effect of ABO blood group on plasma von Willebrand factor (vWF) levels is mediated by the ABH antigenic determinants carried on N-linked glycans of vWF, we studied 158 group A and group O healthy volunteers. vWF antigen (vWF:Ag) and factor VIII antigen (FVIII:Ag) levels were highest in A(1)A(1) individuals and higher in A(1)O(1) than in A(2)O(1) or O(1)O(1) individual...
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ژورنال
عنوان ژورنال: Journal of Clinical Pathology
سال: 2019
ISSN: 0021-9746,1472-4146
DOI: 10.1136/jclinpath-2019-206182